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硒酵母可减少关节炎症

发布日期:2012-02-02 09:00

  巴西的最新研究结果显示,饮食中加入富硒酵母可减少与关节炎有关炎症的发生。

  研究使用了富含有机硒的失活啤酒酵母,研究人员在报告中称,这种矿物质与试验小鼠、大鼠关节组织中炎症前体化合物的减少以及鼠爪中液体积聚的减少存在关系,“‘硒多多’(该品牌产品的有效成分)与受试关节炎动物模型中多组炎症参数、功能参数的改善有关,这些研究结果显示,富硒酵母应该进一步在风湿性关节炎患者身上进行研究。①”来自Minas Gerais联邦大学的研究人员称。

  如果该研究结果可重复出现在其他试验组,特别是人类试验组,那么硒即可被认为是关节健康组分。

  关节健康市场目前以氨基葡萄糖为主,国际欧洲监测组织评估氨基葡萄糖的全球市场金额为20亿美元,并引证指出其2004年到2009年的年增长率为7%。

  矿物质硒

  矿物质硒是一种必需的基础元素,并被认为是一种抗氧化剂。机体高水平的硒含量与几种癌症发展的风险性成负相关,包括膀胱癌、前列腺癌与甲状腺癌。

  这种微量元素自然存在于土壤中,被植物与庄稼吸收后,进入人类食物链--直接进入或者人类通过摄入食草动物的肉或其他产品而进入。该矿物质存在于体内50到100种不同的蛋白质中,功能众多,包括参与心脏肌肉与健康精液的生成。

  研究细节

  为了进行此次的新研究,来自巴西的学者们考察了摄入不同富硒酵母剂量(占食物比重的0.01,0.1,1,10%)的小鼠与大鼠,对照动物组摄入不含富硒酵母的失活酵母。

  研究结果显示,所有摄入剂量都与“膝关节腔内炎症细胞的显著减少”有关。摄入硒的动物组,其炎症前体化合物的水平也更低,包括(肿瘤坏死因子)TNF-α与(白细胞介素)IL-1β。

  要确定人类是否也符合该研究结果,尚需进一步的研究。

  硒的重要性

  来自奥克兰CHORI营养与新陈代谢中心的学者Joyce McCann与Bruce Ames最近的研究报告指出,硒的一般性缺乏即可对身体产生长期有害的影响(FASEB杂志, 2011, 第25卷, 页码1793-1814).

  ①该文献来源:英国营养学期刊

  印刷前即发表于网络,文章首次发表的数字对象唯一标识符:10.1017/S0007114512000013

  “使用硒多多(一种富硒酵母)可改善试验中大鼠和小鼠关节炎症状”

  作者:A.T. Vieira, K.D. Silveira, M.C.C. Arruda,等.

  英文原文:

  Selenium yeast may reduce joint inflammation: Rodent data

  By Elaine Watson, 30-Jan-2012

  Supplementing the diet with selenium-enriched yeast may reduce inflammation linked to arthritis, suggests new research from Brazil.

  Using an inactive yeast (Saccharomyces cerevisiae) enriched with organic selenium, researchers report that the mineral was associated with a reduction in pro-inflammatory compounds in joint tissue of lab mice and rats, and a reduction in fluid build-up in the paws.

  “[The branded ingredient] Selemax is associated with amelioration of several inflammatory and functional parameters in models of arthritis, suggesting that this selenium-enriched yeast should be evaluated further in patients with rheumatoid arthritis,” said researchers from Federal University of Minas Gerais,.

  If the results can be repeated in additional studies, particularly human studies, it could see selenium considered a joint health ingredient.

  The joint health market is dominated by glucosamine. Euromonitor International puts the value of the global market for glucosamine supplements at $2bn, and cites an annual growth rate of 7% from 2004 to 2009.

  The mineral

  The mineral Selenium is an essential macronutrient, and is considered to be an antioxidant. High levels of selenium have been inversely associated with risk of developing several cancers, including bladder, prostate and thryroid.

  The trace element occurs naturally in the soil and is absorbed by plants and crops, from where it enters the human food chain - either directly or through consumption of meat and other products from grazing animals.

  The mineral is included in between 50 and 100 different proteins in the body, with multifarious roles including building heart muscles and healthy sperm.

  However, cancer prevention remains one of the major benefits of selenium, and it is the only mineral that qualifies for a Food and Drug Administration (FDA)-approved qualified health claim for general cancer reduction incidence.

  Study details

  For the new study, the Brazil-based researchers tested different doses of the selenium-enriched yeast (0.01, 0.1, 1 and 10% in food) in lab mice and rats. Control animals were fed non-selenium-enriched inactivated yeast.

  Results showed that all doses were associated with “significantly decreased the number of inflammatory cells recruited to the knee cavity”.

  The selenium-fed animals also had lower levels of proinflammatory compounds, including TNF-alpha, and interleukin (IL)-1beta.

  Additional studies should evaluate if such results can be obtained in humans.

  Importance of selenium

  A recent review paper by Joyce McCann and Bruce Ames from the Nutrition and Metabolism Center at Children’s Hospital Oakland Research Institute in Oakland (CHORI) indicated that moderate deficiency in selenium may have long-term detrimental effects (FASEB Journal, 2011, Vol. 25, pp. 1793-1814).

  Source: British Journal of Nutrition

  Published online ahead of print, FirstView Articles, doi:

  10.1017/S0007114512000013

  “Treatment with Selemax, a selenium-enriched yeast, ameliorates experimental arthritis in rats and mice”

  Authors: A.T. Vieira, K.D. Silveira, M.C.C. Arruda, et al.

  文章出处:

  http://www.nutraingredients.com/Research/Selenium-yeast-may-reduce-joint-inflammation-Rodent-data

  作者:Elaine Watson

  译者:付俊鹤

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